
Research Assistant:
Twin pregnancies are about five times more likely to be complicated by premature birth, preeclampsia, fetal growth restriction, and other pregnancy complications compared with singleton pregnancies. This, in turn, results in a considerable risk of death and illness for both mothers and infants.
Dr. Melamed is head of the Twins Research Centre at Sunnybrook. His research is focused mainly on improving the understanding of the mechanisms of pregnancy complications, fetal growth, and prediction and prevention of preterm birth in twin pregnancies. This work is supported by the Waugh Family Chair in Twins Research held by Dr. Melamed, and by a $1.5 million Canadian Institutes of Health Research Team Grant on noncommunicable diseases in obstetrics.
His research also focuses on placental disease and fetal growth. He uses various approaches including biochemical markers, noninvasive cardiac monitoring, ultrasound and Doppler studies, and placental pathology.
Education
- M.Sc., 2002, biochemistry, Hebrew University, Israel
- MD, 2002, Hebrew University, Israel
- Specialist in obstetrics and gynecology, 2010, Rabin Medical Center, Israel
- Subspecialty in maternal fetal medicine, 2014, University of Toronto, Canada
Appointments & Affiliations
- Program research director, DAN Women & Babies Program,
- Staff physician, Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Sunnybrook Health Sciences Centre,
- Senior scientist, Evaluative Clinical Sciences, DAN Women & Babies Research Program, Sunnybrook Research Institute,
- Professor, Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Toronto,
- Waugh Family Chair in Twins Research,
- Head of the Twins Research Centre at Sunnybrook Health Sciences Centre (https://twincentre.sunnybrook.ca/),
- Head of the Twins Clinic at Sunnybrook Health Sciences Centre,
Affiliated Labs & Programs
Selected Publications
-
Melamed N, Avnon T, Barrett J, Fox N, Rebarber A, Shah BR, Halperin I, Retnakaran R, Berger H, Kingdom J, Hiersch L. Gestational diabetes in twin pregnancies-a pathology requiring treatment or a benign physiological adaptation? Am J Obstet Gynecol. 2024 Jul;231(1):92-104.e4. doi: 10.1016/j.ajog.2024.01.004. Epub 2024 Jan 12. PMID: 38218511. Aviram A, Barrett J, Mei-Dan E, Yoon EW, Melamed N. A prediction tool for mode of delivery in twin pregnancies-a secondary analysis of the Twin Birth Study. Am J Obstet Gynecol. 2024 Jul;231(1):124.e1-124.e11. doi: 10.1016/j.ajog.2023.11.1230. Epub 2023 Nov 17. PMID: 37979823. https://pubmed.ncbi.nlm.nih.gov/37979823/
-
Weitzner O, Barrett J, Murphy KE, Kingdom J, Aviram A, Mei-Dan E, Hiersch L, Ryan G, Van Mieghem T, Abbasi N, Fox NS, Rebarber A, Berghella V, Melamed N. National and international guidelines on the management of twin pregnancies: a comparative review. Am J Obstet Gynecol. 2023 Dec;229(6):577-598. doi: 10.1016/j.ajog.2023.05.022. Epub 2023 May 25. PMID: 37244456.
-
Lipworth H, Amir K, Arruda I, Fockler M, Jung E, Po L, Barrett J, Melamed N. A new care pathway to optimize gestational weight gain in twin pregnancies. Am J Obstet Gynecol MFM. 2023 Aug;5(8):101018. doi: 10.1016/j.ajogmf.2023.101018. Epub 2023 May 13. PMID: 37187262.
-
Hiersch L, Barrett J, Fox NS, Rebarber A, Kingdom J, Melamed N. Should twin-specific growth charts be used to assess fetal growth in twin pregnancies? Am J Obstet Gynecol. 2022 Jul;227(1):10-28. doi: 10.1016/j.ajog.2022.01.027. Epub 2022 Jan 31. PMID: 35114185.