Meaghan O’Reilly
PhD
Senior Scientist
moreilly@sri.utoronto.ca
Phone: 416-480-6100
Fax: 416-480-4696
Research Assistant:
Dr. O’Reilly’s research focuses on developing systems and methods to deliver, monitor and control ultrasound therapy. In particular, she has investigated ways to map and control microbubble activity during targeted drug delivery in the brain and spinal cord.
Her current research interests include the investigation of cavitation-mediated therapies in the central nervous system, including device and methods development, and the study of ultrasound induced bioeffects. Outside the CNS, she is interested in applications of focused ultrasound in musculoskeletal health.
Education
- B.Sc., 2007, mechanical engineering, Queen’s University, Canada
- M.Sc., 2008, biomedical engineering, University of Oxford, U.K.
- PhD, 2012, applied physics, University of Eastern Finland, Finland
Appointments & Affiliations
- Senior Scientist, Physical Sciences, Holland Bone and Joint Research Program, Sunnybrook Research Institute
- Associate Professor, Department of Medical Biophysics, University of Toronto
- Canada Research Chair in Biomedical Ultrasound, Tier 2
Research Foci
- Monitoring and control of ultrasound therapy
- Targeted drug delivery
- Therapeutic ultrasound
Affiliated Labs & Programs
Selected Publications
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Martin D, Xu R, Dressler M, O'Reilly MA. Ex vivo validation of non-invasive phase correction for transspine focused ultrasound: model performance and target feasibility. Phys Med Biol. 2024 Nov 19;69(23).
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O’Reilly MA. Exploiting the mechanical effects of ultrasound for non invasive therapy. Science. 2024. 385, eadp7206. DOI: 10.1126/science.adp7206
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Frizado AP, O’Reilly MA. A numerical investigation of passive acoustic mapping for monitoring bubble-mediated focused ultrasound treatment of the spinal cord. J Acoust Soc AM. 2023. 154(1):361-362.
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Smith, P, Ogronik N, Satkunarajah J, O'Reilly MA. Characterization of Ultrasound-Mediated Delivery of Trastuzumab to Normal and Pathologic Spinal Cord Tissue. Scientific Reports. 2021. 11: 4412.
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Fletcher SP, Choi M, Ogrodnik N, O'Reilly MA. A Porcine Model of Transvertebral Ultrasound and Microbubble-Mediated Blood-Spinal Cord Barrier Opening. Theranostics. 2020; 10(17):7758-7774.