Greg Stanisz
Research Assistant:
Magnetic resonance imaging (MRI) has proved to be a useful diagnostic tool that enables the imaging of soft tissue noninvasively. Measured MRI signal characteristics depend on the physical and chemical processes experienced by water molecules in tissues. Dr. Stanisz’s work involves studies that quantitatively characterize the MRI signal behaviour in various types of normal and pathological tissues in order to obtain information about tissue microstructure and metabolism. Quantitative MRI can be used to estimate physical tissue parameters such as cell dimensions, cell membrane permeability, translational and rotational motion of water in intracellular and extracellular tissue compartments, and extracellular and intracellular volume fractions.
His team is measuring basic MR properties of tissue using a 7T Bruker preclinical MRI system, and developing tissue multicompartmental models in order to correlate experimental data with tissue histopathology data. They are particularly interested in whether nuclear MR measurements such as T1 and T2 relaxation times, diffusion or magnetization transfer between water and macromolecules can be used to evaluate the processes involved in central nervous system pathologies.
In addition, the team is using MRI to monitor cancer therapies in preclinical models of cancer and in patients. In particular, his group is interested in evaluating changes in tumour microstructure and metabolism and the processes of apoptosis (programmed cell death) using combined MRI and MR spectroscopy.
Education
- PhD, 1990, physics, Jagellonion University, Poland
Appointments and Affiliations
- Senior scientist, Physical Sciences, Odette Cancer Research Program, Sunnybrook Research Institute
- Professor, department of medical biophysics, University of Toronto
Selected Publications
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Lam W, Oakden W, Murray L, Klein J, Iorio C, Screaton R, Koletar M, Chu W, Liu S, Stanisz GJ. Differentiation of normal and radioresistant prostate cancer xenografts using magnetization transfer-prepared MRI. Sci Rep. 2018 Jul 11;8(1):10447.
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Mehrabian H, Myrehaug S, H, Soliman H, Sahgal A, Stanisz GJ. Evaluation of glioblastoma (GBM) response to therapy with chemical exchange saturation transfer (CEST). Int J Radiat Oncol Biol Phys. 2018 Jul 1;101(3):713–723. Epub 2018 Apr 4.
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Mehrabian H, Lam WW, Myrehaug S, Sahgal A, Stanisz GJ. Glioblastoma (GBM) effects on quantitative MRI parameters of contralateral normal appearing white matter. J Neurooncol. 2018;139(1).
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Mehrabian H, Myrehaug S, H, Soliman H, Sahgal A, Stanisz GJ. Quantitative magnetization transfer in monitoring glioblastoma multiforme (GBM) response to therapy. Sci Rep. 2018.
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Mehrabian H, Desmond KL, Soliman H, Sahgal A, Stanisz GJ. Chemical exchange saturation transfer in differentiation between radiation necrosis and tumour progression in brain metastasis treated with steriotactic radiosurgery. Clin Cancer Res. 2017;23(14):3667–3675. Epub 2017 Jan 17.