Research Assistant:
Dr. Qian’s lab focuses on research in both basic and translational sciences. The Qian Lab is developing advanced nonlinear vibrational imaging methods, combining physics/chemistry and machine learning tools, aiming to achieve higher throughput for tissue imaging, and to enable fast, precision cancer diagnosis and prognosis. Dr. Qian developed new imaging methods that enabled scalable label-free super-resolution interrogations of protein-rich biological structures, offering new tools for cancer imaging and brain imaging.
Dr. Qian’s research interests also include single cell metabolite imaging. As part of his postdoctoral fellowship at Caltech, Dr. Qian worked with pioneers in cancer therapy and single cell metabolomics, demonstrated the promise of Raman spectro-microscopy for mapping metabolites in single cells, and discovered new druggable metabolic susceptibilities. The Qian Lab at Sunnybrook is developing the next-generation imaging methods for single cell metabolomics studies.
Education
- NSERC Postdoctoral Fellow, Chemistry, California Institute of Technology (Caltech),
- Visiting Scholar, Applied Physics, Stanford University,
- PhD, Chemistry, University of Toronto,
Appointments & Affiliations
- Scientist, Physical Sciences, Odette Cancer Research Program and Hurvitz Brain Research Program, Sunnybrook Research Institute,
Research Foci
- Advanced Optics, AI, cancer, neurodegenerative diseases
- Machine learning aided cell and tissue imaging and fast phenotyping
- Neurodegenerative disease models
- Raman microscopy, stimulated Raman scattering imaging (label-free live cell and tissue imaging, methodology)
- Subcellular metabolomics
- Tissue clearing and high-throughput volumetric imaging
- Tumor microenvironment
- Ultrafast Raman histology and cancer diagnosis/prognosis
Affiliated Labs & Programs
Selected Publications
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Super-resolution label-free volumetric vibrational imaging. Qian C, Miao K, Lin LE, Chen X, Du J, Wei L. Nat Commun. 2021 Jun 15;12(1):3648. doi: 10.1038/s41467-021-23951-x.
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Quantitative Real-Time Analysis of Living Materials by Stimulated Raman Scattering Microscopy. Qian C, et al. Anal. Chem. 2024, 96, 17, 6540–6549
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High spatial-resolution imaging of label-free in vivo protein aggregates by VISTA. Lin LE, Miao K, Qian C, Wei L. Analyst. 2021 Jun 28;146(13):4135-4145. doi: 10.1039/d1an00060h.
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Label-free Super-resolution Imaging Enabled by Vibrational Imaging of Swelled Tissue and Analysis. Miao K, Lin LE, Qian C, Wei L. J Vis Exp. 2022 May 17;(183):10.3791/63824. doi: 10.3791/63824.
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Raman-guided subcellular pharmaco-metabolomics for metastatic melanoma cells. Du J, Su Y, Qian C, Yuan D, Miao K, Lee D, Ng AHC, Wijker RS, Ribas A, Levine RD, Heath JR, Wei L. Nat Commun. 2020 Sep 24;11(1):4830. doi: 10.1038/s41467-020-18376-x.