
Brian H Cuthbertson
Research Assistant:
Dr. Cuthbertson primarily identifies as a Critical Care Physician and prides himself most on my clinical work and clinical identity. His desire to improve the outcomes of critical illness has led him to pursue this aim jointly through striving for clinical, research and teaching excellence.
After clinical practice, it is his research that drives him and he has been lucky enough to have collaborated with some of the world’s great researchers in Critical Care Medicine and far beyond. This has led to a large number of research publications and outputs that have impacted and improved clinical practice and patient outcomes. He has also been lucky to have had the opportunity to have led a large number of national and international research collaborations throughout his career and this exciting work creates many challenges and great personal satisfaction. From a methodological perspective Dr. Cuthbertson has an interest in health technology evaluation using innovative trial designs (including platform trials, cluster trials and other trial methodologies). He has developed broad clinical and academic leadership skills coming from varied leadership roles in clinical practice, research and education including 10 years as the Chief of the Department of Critical Care Medicine at Sunnybrook HSC and in his more recent role as a Departmental Vice Chair of Research at the University of Toronto. He has 240 peer-reviewed publications, $54 million of research grants, an H index of 61 and an i10 index of 156. Dr. Cuthbertson also believes strongly in educating the next generation of researchers in clinical trials methods and enjoys teaching research methods including running a course on pragmatic trials as part of a Masters program.
In the next stage of his career, he plans to focus on further expanding his health technology assessment portfolio by designing, conducting, completing and implementing the highest quality evaluations including large pragmatic clinical trials and varied innovative trials methodologies. At the same time, he hopes to continue playing a key role in delivering and developing research methods education and mentorship.
Education
- MB, ChB Aberdeen, United Kingdom
- FRCA, London, England
- MD, Aberdeen, United Kingdom
Appointments & Affiliations
- Senior Scientist, Evaluative Clinical Sciences, Tory Trauma Research Program, Sunnybrook Research Institute
- Professor, Inter-Departmental Division of Critical Care Medicine and University Department of Anesthesiology and Pain Medicine, University of Toronto
Research Foci
- Application of RCT methods
- Hospital acquired infection
- Outcomes from critical illness
Affiliated Labs & Programs
Selected Publications
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The SuDDICU Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group, Myburgh JA, Seppelt IM, Goodman F, Billot L, Correa M, Davis JS, Gordon AC, Hammond NE, Iredell J, Li Q, Micallef S, Miller J, Mysore J, Taylor C, Young PJ, Cuthbertson BH, Finfer SR. Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial. JAMA. 2022 Nov 15; 328(19): 1911–1921. Published online 2022 Oct 26. doi: 10.1001/jama.2022.179 PMCID: PMC9607966 Co-lead.
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Wijeysundera D, Pearse R, Shulman M, Cuthbertson BH. Assessment of functional capacity before major non-cardiac surgery, a prospective cohort study. Lancet. 2018; 391: 2631-2637. Senior and most responsible author.
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Young D, Lamb SE, Shah S, MacKenzie I, Tunnicliffe W, Lall R, Rowan K, Cuthbertson BH; OSCAR Study Group. High-frequency oscillation for acute respiratory distress syndrome. N Engl J Med. 2013 Feb;368(9):806-13. Senior author.
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Sprung CL, Annane D, Keh D, Moreno R, Singer M, Freivogel K, Weiss YG, Benbenishty J, Kalenka A, Forst H, Laterre PF, Reinhart K, Cuthbertson BH, Payen D, Briegel J; CORTICUS Study Group. Hydrocortisone therapy for patients with septic shock. N Engl J Med. 2008 Jan;358(2):111-24. Coauthor.
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Young D, Harrison DA, Cuthbertson BH, Rowan K, TracMan Collaborators. Effect of early vs late tracheostomy placement on survival in patients receiving mechanical ventilation: the TracMan randomized trial. JAMA. 2013 May;309(20):2121-9. Coauthor.