Alain Dabdoub

Our research program centers on discovering and elucidating the molecular signaling pathways and transcription factors responsible for the neurodevelopment and regeneration of the cochlea (hearing organ), and utricle (balance organ). Our goal is to connect the developmental biology of the inner ear to diseases and ultimately to regenerative medicine for the amelioration of hearing loss and balance disorders.

We carry out a dynamic interdisciplinary and highly collaborative research program centering on:

1. Discovering the molecular underpinnings of sensory hair cell and auditory neuron development and regeneration
2. Developing new approaches of non-invasive delivery of therapeutics to the inner ear
3. Identifying and quantifying inner ear biomarkers that report on the pathologies and treatment efficacies of the inner ear

This research reflects our growing interest in translating our basic science discoveries into regenerative medicine for the diagnosis and treatment of inner ear disorders.

Education

• B.Sc., 1989, zoology, University of Maryland, U.S.A.
• PhD, 1999, biology, University of Maryland, U.S.A.

Appointments and Affiliations

• Senior scientist, Biological Sciences, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute
• Research director, Sunnybrook Hearing Regeneration Initiative, Sunnybrook Health Sciences Centre
• Vice chair of research, department of otolaryngology – head & neck surgery, University of Toronto
• Professor, departments of otolaryngology – head & neck surgery; and laboratory medicine and pathobiology, University of Toronto