Sunnybrook Research Institute (SRI) has an extensive offering of core facilities that serve internal and external users. Here, scientists, postdoctoral fellows, students and other lab members enjoy access to an array of cutting-edge equipment for a multidisciplinary, and often multi-institutional, spectrum of projects.
The Biological Sciences facilities provide services in DNA sequencing and quantification, flow cytometry, histology and microscopy, among others. The current Good Manufacturing Practices Facility offers users a certified and controlled environment to develop cellular therapies for clinical testing, while the Device Development Lab contains specialized machining and prototyping equipment to enable the design, fabrication and testing of medical devices. The Physical Sciences facilities are home to SRI’s suite of imaging systems, which include biomarker imaging, computed tomography and magnetic resonance imaging.
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3T & 7T MRI Systems
Sunnybrook Research Institute operates a variety of magnetic resonance imaging (MRI) and related facilities. A wide range of clinical, preclinical and technical research projects use these resources on a cost recovery basis. The portfolio includes these research-dedicated MRI systems. Registered MRI technologists are available weekdays for human studies. Projects must be approved by the Sunnybrook […]
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7T Preclinical MRI
The preclinical 7T magnetic resonance imaging (MRI) facility at Sunnybrook Research Institute (SRI), under the directorship of Dr. Jamie Near, allows for in-depth, high-quality preclinical imaging research. The Bruker 7T MRI system is ideally suited for preclinical and molecular MRI research. Current research interests being explored include: The ability to perform longitudinal and noninvasive imaging […]
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Advanced Machine Shop
The advanced machine shop is part of the device development lab within the Centre for Research in Image-Guided Therapeutics at Sunnybrook Research Institute. It is a state-of-the-art facility equipped for the design, fabrication and testing of medical devices. It specializes in the manufacture of magnetic resonance imaging-compatible devices, prototypes, custom-made parts and catheter-based devices, and […]
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Antibody
The antibody core facility purifies by affinity chromatography antibodies specific for cell differentiation markers, signalling and tagging molecules of various species. We conjugate these antibodies to various fluorochromes (fluorescein, allophycocyanin, phycoerythrin, and up to 20 different Alexa Fluor dyes), to biotin, and to microbeads for cell surface multicolour immunofluorescence, immunohistochemistry, functional assays and biochemical analyses […]
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Device Development Lab
The creation of novel devices is a cornerstone of medical innovation. In Sunnybrook Research Institute’s device development laboratory—Canada’s first of this scope based in a hospital—scientists and engineers are designing and producing complex medical devices under highly controlled conditions. The aims are to design more effective and safer ways to detect disease, deliver therapy and […]
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Genomics
The mandate of the genomics core facility at Sunnybrook Research Institute (SRI) is to provide cutting-edge genomics services to scientists and clinicians, as well as to academic and clinical collaborators. The facility supports research by clinical departments at Sunnybrook and other major hospitals as they embrace genomic approaches to cancer screening and diagnostics. The genomics […]
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Good Manufacturing Practices Facility
In this Health Canada-regulated facility, research teams are making new biological agents, and cell- and gene-based therapies for testing in clinical trials. It is equipped with four Grade B and C cleanrooms that are used to process and manufacture these products. Having immediate access to this strictly controlled environment ensures that quality is built into […]
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High Content Cellular Analysis Lab
The High-Content Cellular Analysis (HiCCA) lab at Sunnybrook Research Institute (SRI) is a hub for automation and fluorescence applications. Directed by Dr. David Andrews, the HiCCA lab provides platforms for high-throughput and high-content investigations of in vitro model systems, and features custom-designed instrumentation and cutting-edge technologies unique to SRI. The HiCCA lab provides the tools […]
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Histology
The mission of the histology facility at Sunnybrook Research Institute (SRI) is to meet the expanding research needs of basic scientists and clinical researchers who require tissue processing. Our facility offers both standard and tailored research-specific histology services, catering to a diverse range of tissue samples and employing various staining techniques based on specific research […]
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Hypoxic Chamber
The Ruskinn Invivo2 200 hypoxic chamber enables 0.1% incremental control of oxygen and other gases for incubating cells in hypoxia (low oxygen) or anoxia (zero oxygen) experiments. In addition to providing more precision than Sunnybrook Research Institute’s (SRI’s) existing hypoxic technology, the Invivo2 allows multiple simultaneous experiments through an interlock system that maintains oxygen levels […]
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Multiphoton Laser Scanning Microscope
The ability to image tissues noninvasively in vivo at a micrometre spatial resolution has a wide range of applications in preclinical models of disease, particularly in neuroscience. The multiphoton laser scanning microscope at Sunnybrook Research Institute (SRI), under the leadership of Dr. Bojana Stefanovic, allows cutting-edge in vivo neuroimaging. This facility is a centralized resource […]
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Nuclear Polarization Device
Sunnybrook Research Institute’s new Oxford Instruments HyperSense dynamic nuclear polarization (DNP) device (located on the ground floor of S wing, next to the 3T MRI scanner) gives scientists the opportunity to increase the sensitivity, accuracy and depth of their nuclear magnetic resonance experiments to levels never before thought possible. The hospital’s polarizer, operational since early […]
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O-Arm Surgical Imaging System
Sunnybrook is a world leader in the treatment of musculoskeletal (MSK) trauma, arthroplasty and metastases. Intraoperative imaging has revolutionized MSK surgery and yielded significant improvements in clinical outcomes through reducing invasiveness and improving accuracy. However, intraoperative MSK imaging is most often used qualitatively in two dimensions (2-D) and requires high levels of training and experience. […]
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The Centre for Flow Cytometry & Scanning Microscopy (CCSM)
The Centre for Flow Cytometry and Scanning Microscopy (CCSM) at the Sunnybrook Research Institute (SRI) offer the following services: Work is performed on a fee-for-service basis, and is available to internal and external users. Equipment Instruments available for cell sorting Instruments available for flow cytometry Microscope for imaging Contact
